Richard E Lee Selected Research

mycolactone

6/2005	A newly discovered mycobacterial pathogen isolated from laboratory colonies of Xenopus species with lethal infections produces a novel form of mycolactone, the Mycobacterium ulcerans macrolide toxin.
2/2004	Giant plasmid-encoded polyketide synthases produce the macrolide toxin of Mycobacterium ulcerans.
1/2004	Analysis of Mycobacterium species for the presence of a macrolide toxin, mycolactone.

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Richard E Lee Research Topics

Disease

27	Tuberculosis (Tuberculoses) 11/2023 - 03/2003
26	Dehydration (Water Stress) 01/2021 - 11/2005
19	Infections 02/2024 - 06/2005
4	Neoplasms (Cancer) 10/2020 - 11/2003
4	Persistent Infection 01/2017 - 01/2011
4	Buruli Ulcer 06/2005 - 02/2003
3	Bacterial Infections (Bacterial Infection) 01/2019 - 05/2015
3	Hypoxia (Hypoxemia) 11/2018 - 11/2007
3	Multidrug-Resistant Tuberculosis (Drug-Resistant Tuberculosis) 01/2017 - 01/2016
2	Communicable Diseases (Infectious Diseases) 11/2023 - 11/2010
2	Extensively Drug-Resistant Tuberculosis 11/2023 - 02/2014
2	Propionic Acidemia 01/2023 - 09/2021
2	Neuroblastoma 01/2020 - 06/2006
2	Mycoses (Diseases, Fungus) 01/2017 - 06/2005
2	Water Intoxication 08/2011 - 05/2009
2	Glioma (Gliomas) 08/2004 - 11/2003
2	Diarrhea 08/2004 - 06/2004
1	Body Weight (Weight, Body) 10/2023
1	Pantothenate Kinase-Associated Neurodegeneration (Hallervorden-Spatz Disease) 10/2023
1	Granuloma 06/2023
1	Inflammation (Inflammations) 10/2022
1	Acute Myeloid Leukemia (Acute Myelogenous Leukemia) 12/2021
1	Mitochondrial Diseases (Mitochondrial Disease) 09/2021
1	Metabolic Diseases (Metabolic Disease) 09/2021
1	Carcinogenesis 10/2020
1	Melanoma (Melanoma, Malignant) 10/2020
1	Otitis 01/2019
1	Otitis Media 01/2019
1	Hepatocellular Carcinoma (Hepatoma) 01/2019
1	Respiratory Tract Infections (Respiratory Tract Infection) 01/2019
1	Weight Gain 10/2018
1	Weight Loss (Weight Reduction) 10/2018
1	Heart Failure 01/2018
1	Sepsis (Septicemia) 01/2018
1	Immune System Diseases (Immune Disorders) 01/2018
1	Gonorrhea 01/2018
1	Coinfection 01/2018

Drug/Important Bio-Agent (IBA)

21	Anti-Bacterial Agents (Antibiotics)IBA 02/2024 - 09/2006
16	Proteins (Proteins, Gene)FDA Link 12/2021 - 08/2004
9	Urea (Carbamide)FDA LinkGeneric 12/2014 - 11/2005
8	EnzymesIBA 01/2023 - 08/2004
6	TrehaloseIBA 02/2015 - 07/2007
5	Spectinomycin (Spectinomycin Hydrochloride)FDA Link 01/2023 - 02/2014
4	Coenzyme A (CoA)IBA 10/2023 - 10/2018
4	Antitubercular AgentsIBA 01/2017 - 02/2009
4	Glucose (Dextrose)FDA LinkGeneric 02/2015 - 09/2006
4	Irinotecan (Camptosar)FDA LinkGeneric 06/2006 - 11/2003
3	spectinamide 1599IBA 06/2023 - 09/2015
3	IceIBA 09/2008 - 09/2006
3	MacrolidesIBA 06/2005 - 02/2003
3	mycolactoneIBA 06/2005 - 01/2004
2	Linezolid (Zyvox)FDA Link 11/2023 - 01/2016
2	AerosolsIBA 11/2023 - 01/2017
2	pretomanidIBA 11/2023 - 01/2014
2	pantothenate kinaseIBA 10/2023 - 09/2021
2	Peptides (Polypeptides)IBA 01/2022 - 01/2011
2	Aquaporins (Water Channels)IBA 01/2021 - 08/2015
2	UbiquitinIBA 10/2020 - 12/2012
2	Type II Fatty Acid SynthaseIBA 01/2020 - 02/2015
2	Antineoplastic Agents (Antineoplastics)IBA 01/2020 - 06/2004
2	Messenger RNA (mRNA)IBA 01/2019 - 08/2012
2	ProdrugsIBA 02/2015 - 06/2006
2	Glycerol (Glycerine)FDA LinkGeneric 02/2015 - 07/2007
2	LipidsIBA 01/2014 - 04/2012
2	Mycolic Acids (Mycolic Acid)IBA 01/2014 - 02/2012
2	GlycogenIBA 09/2013 - 04/2012
2	Epoxide HydrolasesIBA 05/2012 - 09/2011
2	Ethambutol (Myambutol)FDA LinkGeneric 03/2008 - 03/2003
2	Lactic Acid (Lactate)FDA LinkGeneric 09/2006 - 05/2005
2	mycolactone AIBA 06/2005 - 02/2003
2	Carboxylesterase (Hydrolase S)IBA 08/2004 - 06/2004
2	PolyketidesIBA 01/2004 - 02/2003
1	bedaquiline (R207910)IBA 11/2023
1	Propionyl-Coenzyme A Carboxylase (Propionyl CoA Carboxylase)IBA 01/2023
1	AminoglycosidesIBA 01/2023
1	ChemokinesIBA 10/2022
1	Interleukin-8 (Interleukin 8)IBA 10/2022
1	Carrier Proteins (Binding Protein)IBA 01/2022
1	snake venom protein C activatorIBA 12/2021
1	propionyl-coenzyme A (propionyl-CoA)IBA 09/2021
1	BuffersIBA 11/2020
1	AntigensIBA 10/2020
1	Ligases (Synthetase)IBA 10/2020
1	Hydro-Lyases (Dehydratases)IBA 01/2020
1	Cytotoxins (Cytolysins)IBA 01/2020
1	hydrazine (hydrazine dihydrochloride)IBA 01/2019
1	Isoniazid (Ftivazide)FDA LinkGeneric 01/2019
1	Vitamin B 6IBA 01/2019
1	NitratesIBA 11/2018
1	NitritesIBA 11/2018
1	Nitric Oxide (Nitrogen Monoxide)FDA Link 11/2018
1	Azithromycin (Zithromax)FDA LinkGeneric 01/2018
1	Gentamicins (Gentamicin)FDA LinkGeneric 01/2018
1	Ampicillin (Omnipen)FDA LinkGeneric 01/2018
1	Ceftriaxone (Ceftriaxon)FDA LinkGeneric 01/2018
1	Fungal ProteinsIBA 01/2017

Therapy/Procedure

17	Therapeutics 12/2022 - 10/2004
6	Fluid Therapy (Oral Rehydration Therapy) 08/2015 - 05/2009
5	Drug Therapy (Chemotherapy) 01/2020 - 03/2003
1	Contraception (Birth Control) 01/2018